Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. New features to this edition include: tissue-specific interventions to arrest or cure autoimmune disease; bone marrow eradication and replacement; both basic science and clinical medicine is covered; and boxed points to emphasize key features of each chapter.