A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge of interest in the subject. In this volume, the complexities of eukaryotic DNA replication are reviewed by leaders in this rapidly advancing field. The book begins with reviews of the molecular and genetic components of the replication machinery, and builds into a picture of how the replication process is regulated within the cell division cycle. Topics include the initiation of replication, origin recognition, the enzymology of the replication fork, and how replication is coordinated with other cell cycle events. Although there are undoubtedly many new discoveries to come, this book should form a basis on which researchers in molecular biology, cellular development, and other subject areas can build a dynamic understanding.