RNA-Protein Interactions: A Practical Approach provides a clear and comprehensive guide to the many experimental procedures used in studying RNA-protein interactions. The approaches covered range from those initially used to detect a novel RNA-protein interaction to various biochemical and genetic approaches, and from in-depth methods for analyzing the structural basis of the interaction to methods for purifying and cloning RNA binding proteins. The volume contains a number of procedures that have not previously been covered in this type of manual, including the production of site-specifically modified RNAs by enzymatic and chemical methods and in vivo screening for novel RNA-protein interactions in yeast and E. coli. This informative book will be a valuable aid to laboratory workers in biochemistry and molecular biology, as well as graduate students and postdoctoral and senior scientists, whose research encompasses this field.