It began as a weekend among friends. Biking enthusiasts Brick, David, and Derek are off for a weekend of serious mountain biking when a chance meeting with a mysterious and wealthy stranger-and his equally mysterious lady friend-takes them off course and straight down the road of a rattlesnake. As the three men rally around their newly acquired-and newly bitten-friend they remain unaware of the dangers that are still ahead. "Rattlesnake" winds and twists down out of the mountains of Colorado to the streets of Manhattan, where these three friends and their families will learn just how much they can handle when the real rattlesnake strikes.