Part I: Introduction 1. Molecular Genetics and Genetic Variation Mohammed Elfatih Twfieg and M. Dawn Teare 2. Terminology, Concepts, and Models in Genetic Epidemiology M. Dawn Teare and Mauro F Santibàñez Koref 3. An Introduction to Epidemiology Cother Hajat Part II: Genetic Linkage Mapping 4. Genetic Distance and Markers Used in Linkage Mapping Kristina Allen-Brady and Nicola J. Camp 5. Approaches to Genetic Linkage Analysis M. Dawn Teare Part III: Genetic Mapping by Association 6. Fine-Scale Structure of the Genome and Markers Used in Association Mapping Karen Curtin and Nicola J. Camp 7. Genome-Wide Association Studies Mark M. Iles 8. Candidate Gene Association Studies M. Dawn Teare 9. Family-Based Association Studies Frank Dudbridge 10. Genome Variation: A Review of Web Resources Andrew Collins and William Tapper Part IV: Emerging Themes 11. Advanced Methods in Twin Studies Jaakko Kaprio and Karri Silventoinen 12. Mendelian Randomization: A Tool for Assessing Causality in Observational Epidemiology Nuala A. Sheehan, Sha Meng, and Vanessa Didelez 13. Copy Number Variation Louise V. Wain and Martin D. Tobin 14. Epigenetic Variation Kevin Walters Part V: Case Studies 15. Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis Hervé Perdry and Françoise Clerget-Darpoux 16. Coronary Artery Disease: An Example Case Study Jennifer H. Barrett 17. The Genetic Epidemiology of Obesity: A Case Study Laura Johnson