1. Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint José Rueff and António S. Rodrigues2. Classical and Targeted Anti-Cancer Drugs: An Appraisal of Mechanisms of Multidrug ResistanceBruce C. Baguley3. In Vitro Methods for Studying the Mechanisms of Resistance to DNA Damaging Therapeutic DrugsPasarat Khongkow, Anna K. Middleton, Jocelyn P.-M. Wong, - Navrohit K. Kandola, Mesayamas Kongsema, Gabriela Nestal de Moraes, Ana R. Gomes, and Eric W.-F. Lam4. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and RifampicinRomi Ghose, Pankajini Mallick, Guncha Taneja, Chun Chu, and Bhagavatula Moorthy5. Uptake and Permeability Studies to Delineate the Role of Efflux TransportersRamya Krishna Vadlapatla, Dhananjay Pal, and Ashim K. Mitra6. Dynamics of Expression of Drug Transporters: Methods for AppraisalMarta Gromicho, José Rueff, and António S. Rodrigues7. Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane TransporterAna Armada, Célia Martins, Gabriella Spengler, Joseph Molnar, Leonard Amaral, António S. Rodrigues, and Miguel Viveiros8. Resistance to Targeted Therapies in Breast CancerSofia Braga9. MicroRNAs and Cancer Drug ResistanceBruno Costa Gomes, José Rueff, and António S. Rodrigues10. The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR AnalysisIngrid Garajová, Tessa Y.S. Le Large, Elisa Giovannetti, Geert Kazemier, Guido Biasco, and Godefridus J. Peters11. Methods for Studying MicroRNAs Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer TissuesBruno Costa Gomes, Bruno Santos, José Rueff, and António S. Rodrigues12. The Regulatory Role of Long Non-Coding RNAs in Cancer Drug ResistanceMarjan E. Askarian-Amiri, Euphemia Leung, Graeme Finlay, and Bruce C. Baguley13. Cancer Exosomes as Mediators of Drug ResistanceMaria do Rosário André, Ana Pedro, and David Lyden14. Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma TumorsHong S. Kim, Alexander T. Pearson, and Jacques E. Nör15. Clinical and Molecular Methods in Drug Development: Neoadjuvant Systemic Therapy in Breast Cancer as a ModelSofia Braga16. Proteomics in the Assessment of the Therapeutic Response of Anti-Neoplastic Drugs: Strategies and Practical ApplicationsVukosava Milic Torres, Lazar Popovic, Fátima Vaz, and Deborah Penque17. Managing Drug Resistance in Cancer: Role of Cancer InformaticsAnkur Gautam, Kumardeep Chaudhary, Rahul Kumar, Sudheer Gupta, Harinder Singh, and Gajendra P.S. Raghava