1. The Application of Structure Activity Relationships to the Prediction of the Mutagenic Activity of Chemicals Philip Judson 2. Bacterial Mutagenicity Assays: Test Methods David Gatehouse 3. The Mouse Lymphoma Assay Melvyn Lloyd and Darren Kidd 4. Mammalian Cell HPRT Gene Mutation Assay: Test Methods George E. Johnson 5. The In Vitro Mammalian Chromosome Aberration Test Gill Clare 6. The Interpretation and Analysis of Cytogenetic Data Natalie Danford 7. The In Vitro Micronucleus Assay Ann T. Doherty 8. The In Vitro and In Vivo Comet Assays Brian Burlinson 9. Assessment of DNA Interstrand Crosslinks (ICLs) Using the Modified Alkaline Comet Assay Jian Hong Wu and Nigel J. Jones 10. 32P-Postlabelling for the Sensitive Detection of DNA Adducts Nigel J. Jones 11. Methods for the Detection of DNA Adducts Karen Brown 12. The GADD45a-GFP GreenScreen HC Assay Richard M. Walmsley and Matthew Tate 13. Real Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR): Technical Considerations for Gene Expression Analysis Shareen H. Doak and Zoulikha M. Zaïr 14. Cytogenetic In Vivo Assays in Somatic Cells Ann T. Doherty, Adolph Baumgartner, and Diana Anderson 15. Cytogenetic Methods in Human Biomonitoring: Principles and Uses Raluca A. Mateuca, Ilsa Decordier, and Micheline Kirsch-Volders 16. The Measurement of Induced Genetic Change in Mammalian Germ Cells Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo 17. Transgenic Animal Mutation Models: A Review of the Models and How They Function Steve Dean 18. Analysis of Genotoxicity Data in a Regulatory Context Ian de G. Mitchell and David O.F. Skibinski