Harrison Bishop, once humanity's most beloved playboy, has vanished. The world is in chaos after the spread of the Adversus Anaerobius outbreak, the only known bacteria able to resist The Episcopus Aerobium vaccine. As the epidemic's death toll continues to climb and wanted on charges of mass murder, Harrison Bishop is in hiding as he rises to the top of the FBI's most wanted list, while scientists are incapable of producing a cure. As the infection rapidly spreads without a vaccine, Daisy Stone must leave her place at the helm of the cataclysmic Bishop Enterprises to retrieve Harrison and convince him to return home. With an ending that turns this series upside down, Harrison must choose to either save himself from damnation or return to New Orleans in an attempt to rescue humanity once again - and risk being burned at the stake for his crimes.