This report deals with hypothetical reentry thermostructural performance of the Space Shuttle orbiter with missing or eroded thermal protection system (TPS) tiles. The original STS-5 heating (normal transition at 1100 sec) and the modified STS-5 heating (premature transition at 800 sec) were used as reentry heat inputs. The TPS missing or eroded site is assumed to be located at the center or corner (spar-rib juncture) of the lower surface of wing midspan bay 3. For cases of missing TPS tiles, under the original STS-5 heating, the orbiter can afford to lose only one TPS tile at the center or two TPS tiles at the corner (spar-rib juncture) of the lower surface of wing midspan bay 3. Under modified STS-5 heating, the orbiter cannot afford to lose even one TPS tile at the center or at the corner of the lower surface of wing midspan bay 3. For cases of eroded TPS tiles, the aluminum skin temperature rises relatively slowly with the decreasing thickness of the eroded central or corner TPS tile until most of the TPS tile is eroded away, and then increases exponentially toward the missing tile case.Ko, William L. and Gong, Leslie and Quinn, Robert D.Armstrong Flight Research CenterSPACE SHUTTLE ORBITERS; THERMAL PROTECTION; TILES; EROSION; UNCONTROLLED REENTRY (SPACECRAFT); SPACE TRANSPORTATION SYSTEM; AEROTHERMODYNAMICS; ALUMINUM; SKIN TEMPERATURE (NON-BIOLOGICAL); AERODYNAMIC HEATING; WINGS; COLUMBIA (ORBITER); MACH NUMBER; RIBS (SUPPORTS)...