High-cycle fatigue-induced failures in turbine and turbopump blades is a pervasive problem. Single-crystal nickel turbine blades are used because of their superior creep, stress rupture, melt resistance, and thermomechanical fatigue capabilities. Single-crystal materials have highly orthotropic properties making the position of the crystal lattice relative to the part geometry a significant and complicating factor. A fatigue failure criterion based on the maximum shear stress amplitude on the 24 octahedral and 6 cube slip systems is presented for single-crystal nickel superalloys (FCC crystal). This criterion greatly reduces the scatter in uniaxial fatigue data for PWA 1493 at 1,200 F in air. Additionally, single-crystal turbine blades used in the Space Shuttle main engine high pressure fuel turbopump/alternate turbopump are modeled using a three-dimensional finite element (FE) model. This model accounts for material orthotrophy and crystal orientation. Fatigue life of the blade tip is computed using FE stress results and the failure criterion that was developed. Stress analysis results in the blade attachment region are also presented. Results demonstrate that control of crystallographic orientation has the potential to significantly increase a component's resistance to fatigue crack growth without adding additional weight or cost.Swanson, G. R. and Arakere, N. K.Marshall Space Flight CenterSINGLE CRYSTALS; CRYSTAL LATTICES; CRYSTALS; CRYSTALLOGRAPHY; NICKEL ALLOYS; HEAT RESISTANT ALLOYS; TURBINE BLADES; BLADE TIPS; TURBINE PUMPS; FATIGUE (MATERIALS); FATIGUE LIFE; SHEAR STRESS; STRESS ANALYSIS; FINITE ELEMENT METHOD; FAILURE; CRACK PROPAGATION; CREEP PROPERTIES...