The talented detective Sherbert M. Holmes (an orange and white long hair cat) and his older sister Dr. Pipper (a travel-size calico cat) continue their detective duties when family friend Mr. Sully (an oversized yellow lab) recruits the detective duo to find a missing friend. The case takes the detective duo out of their comfort zone to investigate the infamous Dog Bone Alley. The detective duo gets more than they bargained for when the pair accumulate a gaggle of overly helpful new acquaintances while searching for Mr. Sully's missing friend, a poodle named Fifi. Join the legendary detective Sherbert M. Holmes and his loyal assistant Dr. Pipper as they search for clues, with some help from new friends, to find the missing Fifi from Dog Bone Alley!