Excessive reactive oxygen species (ROS) damage cell membrane, cellular components, and cause oxidative damage. They also lead to various human disorders such as diabetes, cancer, Alzheimer, rheumatoid arthritis and inflammation. Exploration of natural and safer antioxidants from bio-resources and their replacement with synthetic antioxidants is highly commanded. Lactic acid bacteria (LAB) is an emerging natural source of cellular antioxidants. LAB are diversely dispersed in nature. Previously LAB isolate from dairy products and some from human fecal matter. Information about few isolated strains of LAB is available from farm animals.